The mTOR pathway is a major regulator of autophagy activated downstream of PI3K-Akt, a pathway commonly dysregulated in human cancer (4) and activated by HER2, insulin-like growth factor receptor, and estrogen receptor in breast cancer (5–8), suggesting that it may play an important role in the development of cancer and many other diseases (9). This evidence concerns the gene AKT1 and breast carcinoma.