As shown in Figure 1, age was an associated risk factor for HCC development (p<0.01) but the common A1762T/G1764A dual mutation in BCP failed to show significant correlation in both HBeAg positive [89% (8/9)] and negative HCC [69% (9/13)] compared to non-HCC [60% (12/20); p = 0.2 and 42% (10/24); p = 0.17 in HBeAg positive and negative cases respectively]. The gene discussed is OPN1SW; the disease is hepatocellular carcinoma.