Mutation C1653T in enhancer-II and T1753C in BCP, which were reported previously as risk factor for HCC in HBV-genotype C [24], were not observed with significantly enhancing frequencies from nLF to HCC through LF and LC in HBV-genotype D infection (p = 0.079, 0.14 respectively). This evidence concerns the gene OPN1SW and hepatocellular carcinoma.