In accordance to the previously identified risk factors for HCC such as male sex, age>50 yrs, high serum ALT level, HBeAg, high HBV DNA level, HBV genotype C and D and point or combination of mutations in BCP, precore and pre S as powerful contributor in CHB patients [56]–[58], this study has identified late age, high ALT and several point and combination of mutations in BCP, precore, core and surface as predictors of HCC in HBV genotype D infected CHB patients (p<0.05). The gene discussed is OPN1SW; the disease is hepatocellular carcinoma.