MX1 and viral infectious disease: The up-regulation of Mx transcription together with that of TLR3 seems to corroborate the capacity of the virus to transcribe viral genes in the AT, because TLR3 senses intracellular double stranded RNA generated during the course of viral infections [36], and Mx protein, one of the most important proteins induced by type I IFN, usually correlates well with VHSV transcription levels [37].