APP and early-onset autosomal dominant Alzheimer disease: For instance, let-7d, miR-191 and miR-301a make part of a unique circulating 7-miRNA signature that can distinguish patients with Alzheimer’s disease from normal controls [51], and miR-20a and miR-106b are both implicated in transcriptional inhibition of Alzheimer’s amyloid precursor protein (APP) [52].