Subsequently, NF2 gene (located at 22q12.2) inactivation was found to be due to several mechanisms, such as mutations or allelic loss due to monosomy or deletion of chromosome 22, accounting for up to 66% in schwannomas (4) and 18–50% in sporadic meningiomas, depending on the histopathological subtypes (5). This evidence concerns the gene NF2 and meningioma.