In the present study, we investigated the expression of NRP-1 and VEGFR-2 in the tumoral and peritumoral tissues by tissue microarrays and immunohistochemistry from 214 treatment-naïve HCC patients who had received curative hepatectomy at our institution and analyzed whether their expression correlated with the overall survival (OS) and time to recurrence (TTR). The gene discussed is NRP1; the disease is hepatocellular carcinoma.