Moreover, patients with low peritumoral expression of both NRP-1 and VEGFR-2had the highest MVD (tumor: 9.05%±0.12%; peritumoral tissue: 4.16%±0.08%) while patients with high peritumoral expression of both NRP-1 and VEGFR-2 had the lowest MVD (tumor: 2.20%±0.02%; pritumoral tissue: 0.33%±0.01%; both were p < 0.001). The gene discussed is NRP1; the disease is neoplasm.