KDR and hepatocellular carcinoma: In the present study, we investigated the expression of NRP-1 and VEGFR-2 in the tumoral and peritumoral tissues by tissue microarrays and immunohistochemistry from 214 treatment-naïve HCC patients who had received curative hepatectomy at our institution and analyzed whether their expression correlated with the overall survival (OS) and time to recurrence (TTR).