These suggest a possibility that repression of UGT2B15 and UGT2B17 in PCa cells may contribute to stromal TGF-β signaling induced ligand-dependent AR activation in PCa cells, which warrants future studies on the functional roles of these two UDP-glucuronosyltransferases in regulating prostate stroma induced AR activation in PCa cells. The gene discussed is UGT2B17; the disease is posterior cortical atrophy.