Interestingly, our microarray study and qPCR analysis revealed that stromal TGF-β signaling strongly repressed expression of UGT2B17 (Table 1b), as well as UGT2B15 (data not shown), two key epithelium-specific UDP-glucuronosyltransferases for glucuronidation and inactivation of testosterone and DHT ligands for their efficient clearance from normal prostate epithelial cells as well as PCa cells [42, 43]. This evidence concerns the gene TGFB1 and posterior cortical atrophy.