Furthermore, BRCA1/2-related breast cancers also presented a higher percentage of VEGFA, HIF1A, FAK and ANGPT2 gene overexpression compared to the BRCAX breast tumour group (VEGFA: 62% vs 9%, p=0.04; HIF1A: 62% vs 0%, p=0.004; FAK: 62% vs 18%, p=0.073; ANGPT2: 50% vs 45%, p= 1.00). This evidence concerns the gene HIF1A and breast cancer.