TRIM16 and melanoma: Low TRIM16 expression in melanoma cells metastatic to lymph nodes was significantly associated with poor prognosis [(Hazard ratio 0.6322 with 95% confidence of 0.4322 to 0.9383) vs (Hazard ratio 1.582 with 95% confidence of 1.066 to 2.314) (P = 0.0255, two-sided log-rank test; n = 170)] (Fig. 4C&D).