A meta-analysis on 37 retrospective and 11 prospective epidemiological studies with 15,492 cases of CHD and 32,965 controls reported that CHD odd ratio (OR) was 1.42 (1.26–1.61) in APOE4 carriers compared to homozygous carriers of APOE3 [23]. The gene discussed is APOE; the disease is coronary artery disorder.