Furthermore, disease alleles were observed for other autosomal dominantly inherited degenerative diseases of sensory function, including retinitis pigmentosa (SEMA4A, RP1), deafness (MYO1A), glaucoma (CYP1B1, OPTN, WDR36), and keratoconus (VSX1). This evidence concerns the gene OPTN and neurodegenerative disease.