GRN and Alzheimer disease: Both p.Val519Met (NM_002087.2:c.1555G>A) and p.Cys222Tyr (NM_002087.2:c.665G>A) variants in GRN were significantly associated with AD compared with the unrelated controls under the three different models (P < 6.8E-08 and P < 5E-04, respectively).