While a variant in MAPT, p.Ser318Leu (NM_016835.4:c.953C>T), was also frequent (5.5%) among controls as shown in Table 3, the allelic association with AD was significant; however, the other rare variant, p.Ile468Thr (NM_016835.4:c.1403T>C), was not. This evidence concerns the gene MAPT and Alzheimer disease.