In the present study we investigated plasma levels of the endothelium-specific biomarkers endocan and E-selectin, and we describe that combined analysis of these biomarkers (either the two markers alone or together with D-dimer and CRP) could be used to identify patient subsets with different frequencies of DVT in a group of consecutive/unselected patients admitted to hospital with suspected DVT. The gene discussed is ESM1; the disease is deep vein thrombosis.