While the peak association with SLE was originally identified at an intronic SNP rs6445975 in PXK (a PX domain containing serine/threonine kinase), the strongest association with SSc on the Immunochip was at a missense SNP rs35677470 (R206C) in DNASE1L3 (deoxyribonuclease I-like 3); 187 kb distal of rs6445975. This evidence concerns the gene MARK2 and systemic sclerosis.