Furthermore, the activation of Wnt signaling by inflammatory stimuli may induce gastric carcinomas in the K19-Wnt1/C2mE transgenic mouse model of gastric cancer (Gan mouse), which expresses transgenic Wnt1, cyclooxygenase (COX) 2, and microsomal prostaglandin E synthase-1 under the control of the K19 promoter [12]. Here, PTGES is linked to gastric cancer.