CAMK4 and Stroke: Furthermore, the loss of CaMK IV significantly increased hemorrhagic transformation as evaluated by a hemoglobin assay 72 hours after stroke (82.5 ± 8.6 μg/hemisphere in the WT versus 207.3 ± 33.2 μg/hemisphere in the CaMK IV KO, p < 0.05, n = 8 for each group) (Figure 2G and H).