Given in our previous studies, our research teammate Wen et al. [51] have proved that there were abnormal expression of Ca2+-CaM-CaMKIIα pathway in the mPFC neurons, and dysfunction of cytosolic Ca2+ concentration was taken as one of inducement of ER stress, we deduced that ER stress would be induced by dysfunction of Ca2+-CaM-CaMKIIα pathway in the mPFC neurons. The gene discussed is CAMK2A; the disease is Endoplasmic Reticulum Stress.