MAPT and Alzheimer disease: Recently, Lasagna-Reeves et al. [18] have immunopurified tau oligomers from AD brains that could propagate tauopathy in living mice, and such oligomers shared several similarities with synaptic tau oligomers found in this study: (1) they migrated as smears between 75-300 kDa in SDS-PAGE; (2) they were microscopic, amorphous aggregates instead of fibrillar.