Contrarily, the CHF and NAM mice displayed a significant increase of mTORC1, p-mTOR, p-p70S6K, NFκB and p53, and a significant decrease of SIRT1, SIRT6, FOXO3a and NRF-1 proteins compared to the NC and SRT mice (Figure 6). The gene discussed is NRF1; the disease is congestive heart failure.