PAX3 and glioblastoma: Although results herein show a lack of Pax3 upregulation and function in cerebral cortex gliomas of mice, Chen et al. showed that Pax3 levels correlate with increasing WHO grade of supratentorial gliomas [32] and subsequently Xia et al. showed that Pax3 functionally promotes survival of GBM cell lines and xenografts originally isolated from supratentorial tumors [33].