We have found mouse BSG to harbor a distinct expression pattern of developmental homeobox genes and transcription factors, including Pax3, Irx5, Foxg1, and Lhx2. Overall, these observations are similar to those made by others in comparing human infratentorial to supratentorial low-grade glioma [20], and BSG to other pediatric high-grade glioma [5]. Here, IRX5 is linked to central nervous system cancer.