PAX3 and central nervous system cancer: As Pax3 has been found expressed in cerebral cortex glioma [32], infratentorial low-grade glioma [20], as well as high grade BSG as shown here, it appears that Pax3 is expressed in glioma (albeit at different levels) regardless of the tumor grade or location, and may play a functional role in all scenarios dependent on the context of additional genetic alterations.