PDSS2 and cancer: They reported that the forced overexpression of PDSS2 caused massive cell death through apoptotic pathways and significantly inhibited colony formation and there was an inverse correlation between PDSS2 expression and gelsolin expression, which is known to inhibit apoptosis and enhance cell invasion and metastasis [29], though PDSS2 did not influence the sensitivity of the cancer cells to chemotherapeutic drugs [28].