The tumor suppressive function of PDSS2 are supported by the present findings as follows: (1) decreased expression of PDSS2 was frequently detected in GC tissues, (2) the mean level of PDSS2 expression was significantly lower in GC tissues, and (3) decreased expression of PDSS2 was associated with early recurrence and subsequent poor prognosis. This evidence concerns the gene PDSS2 and neoplasm.