In accordance,suppression of autophagy by chloroquine (CQ), an inhibitor of autophagosome–lysosome fusion(Klionsky et al, 2012), revealed highautophagy flux (LC3-II accumulation) and efficient killing of both mouse and humanPten/p53-deficient tumor cells as compared to immortalized mammary epithelial cells or human luminalBC cells (Fig7E and F). The gene discussed is TP53; the disease is neoplasm.