MAPK8 and neoplasm: eEF2K has alsobeen implicated in autophagy (Wu et al, 2009; Cheng et al, 2010).Interestingly, JNK is also linked to this process and, consistent with this, we found thatPten/p53-deficient tumor cells exhibit elevated autophagy flux and high sensitivity to theautophagosome–lysosome inhibitor CQ.