SMAD2 and Familial prostate cancer: miR-106b, a member of miR-106∼25 cluster, has been shown to down regulate the expression levels of TGFBR2, SMAD2 and BMP family genes in CRC [84], miR-126-3p to suppress breast cancer metastasis [85], and miR-126-5p to inhibit the migration and invasiveness of prostate cancer cells [86]; the function of their corresponding miRNA* sequences observed in this study awaits further experimentation.