These studies led to the finding, based upon proteome profiling, that two distinct populations of exosomes (A33-Exos and EpCAM-Exos) are released from LIM1863 colon carcinoma cell-derived organoids into cell culture medium, along with sMVs, and that both exosome populations differ significantly at the protein level from sMVs [4]. This evidence concerns the gene EPCAM and colon carcinoma.