Figure 4 shows that mice treated with capsaicin (0.3 mg/kg) showed less Ly-6B.2 positive cells in kidneys after I/R injury compared to control mice after AKI (Figure 4A, 17.95±4.54 per field view, n = 5 vs 41.62±6.23 per field view, n = 4, respectively, P<0.05). Kidneys of mice treated with capsazepine (50 mg/kg, Figure 4A, 47.40±10.7 per field view, n = 5, P>0.05) or Trpv1−/− mice (Figure 4A, 31.9±5.47, n = 4, P>0.05) showed Ly-6B.2 positive cells similar to control mice after I/R injury. The gene discussed is TRPV1; the disease is acute kidney injury.