TRPV1 and acute kidney injury: Although the relatively high concentration of capsaicin used in this study to activate TRPV1 in vivo may have additional effects not related to TRPV1, these three injury parameters demonstrated a beneficial role of capsaicin in I/R-induced AKI as previously reported by other groups for capsaicin and other TRPV1 agonists [9], [10], [11].