TAT and Schnyder corneal dystrophy: These events collectively could be followed by activation of both coagulation cascade as evidenced previously by elevated plasma levels of thrombin-antithrombin (TAT) complexes, prothrombin fragment 1.2 (F1.2), and D-dimer [49], [50], as well as increased platelet activation [51] in patients with SCD, all of which contribute to a systemic hypercoagulable state [52], and inflammatory pathways.