Genetic abnormalities have linked multiple genes and signaling pathways to NSCLC, including epidermal growth factor receptor (EGFR) family, signal transducer and activator of transcription 3 (Stat3), and phosphoinositide 3-kinase–Akt–mTOR pathways [1], [2], [4]. Here, STAT3 is linked to non-small cell lung carcinoma.