CASP3 and squamous cell carcinoma: The aim of the present study was two-fold: (a) to analyze the anti-proliferative and apoptotic effects of naringenin through ROS mediated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nuclear condensation, mitochondrial membrane potential and DNA fragmentation, and (b) cell cycle kinetics and caspase-3 induction as biomarkers in cancer cell viz. human epidermoid carcinoma A431 cell.