Highly significant pairwise correlations were found between expression levels of APP and MAP2, of AIF1 (IBA1) and CD68, and of IL1R1 and TNFRSF1A. APP, a component in Alzheimer's disease pathogenesis, normally helps to maintain functional synapses [95]. The gene discussed is IL1R1; the disease is early-onset autosomal dominant Alzheimer disease.