ATG12 and acute disseminated encephalomyelitis: In conclusion, several mechanisms have been previously proposed for ADE in dengue disease pathogenesis including promoting viral entry into FcR-bearing cells, the induction of IL-10 to inhibit the IFN-mediated anti-viral pathway, and the activation of DAK and Atg5-Atg12 to inhibit IFN production [33], [48].