In total, 3 variables were found to be significantly associated with overall survival (OS) in univariate Cox regression analysis (Table 2): a) a tumor diameter less than 5 cm (P = 0.007, HR = 0.4), b) AFP under 8 IU/ml (P = 0.015, HR 0.4) and c) negative nuclear CYLD expression (nucCYLD− = IHS≤3, P = 0.02, HR = 2.1). The gene discussed is AFP; the disease is neoplasm.