We focused primarily on transcripts associated with CALM count, an easily-measured, highly-heritable [13] phenotype; CALM are tumor-like in that they arise from biallelic inactivation of NF1. Identification of MSH6 in the screen also prompted us to sequence MSH2 and MLH1, whose protein products are known to associate with MSH6. The gene discussed is MSH6; the disease is neoplasm.