GPT and Insulin resistance: The progression of insulin resistance contributes to the pathogenesis of NAFLD.10 In our results, many of the SM species containing saturated acyl chains positively correlated with the parameters of liver function (aspartate aminotransferase, alanine aminotransferase, γ-GTP and ChE levels, Table 3), suggesting that the increase in the levels of these SM species is related to the pathogenesis of NAFLD.