Previous hypothesis about the possible mechanisms involved in DM-related cancer was the abnormal increase of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the serum that can lead to the occurrence of tumors by promoting the transformation and proliferation of colorectal epithelial cells, influencing the cell cycle and inhibiting cell apoptosis. Here, VEGFA is linked to cancer.