Associated with LT-Ag and RB1expression and absence of TP53 expression, and was associated with improved disease specific and overall survival (p < 0.01) on univariate analysis [95]. Polyomavirus-positive Merkel cell carcinomas showed better prognosis with one spontaneous regression case and significantly higher expression of retinoblastoma protein (p = 0.0003) and less TP53 expression (p = 0.0005) compared to MCPyV negative MCC [32]. The gene discussed is TP53; the disease is Merkel cell skin cancer.