CD4 and HIV infectious disease: In our cohort, DP patients appear to be older and present a lower CD4 T-cell nadir, albeit not statistically significant when compared to the other subject groups; these findings are in line with literature data showing a higher prevalence of non-infectious co-morbidities in the aging population and in patients with a history of advanced HIV infection [10], thus reinforcing our findings on a peculiar iNKT phenotype in this setting.