To determine if Ntf3 overexpression could either prevent, or promote recovery from, this noise-induced synaptic loss and attenuation of cochlear responses, we exposed control and Ntf3 overexpressing mice to noise levels known to cause this type of neuropathy (8–16 kHz at 100 dB SPL for 2 hr) (Kujawa and Liberman, 2009). The gene discussed is NTF3; the disease is neuropathy.