Best-1 is mainly localized in the basolateral membrane of the retinal pigment epithelial, and mutations in Best-1 are also responsible for several other forms of retinopathy, including adult-onset vitelliform macular dystrophy [14], Bull’s eye maculopathy [15], and autosomal dominant vitreoretinochoroidopathy [16]. This evidence concerns the gene BEST1 and Bull's eye maculopathy.