For example, attenuation of 14-3-3 (a negative regulator of ASK1) in diabetic mice worsened cardiomyopathy, suggesting that the up regulation of 14-3-3 (and subsequent prevention of ASK1 activation) would be beneficial in lessening ventricular dysfunction associated with diabetic cardiomyopathy [8]. The gene discussed is MAP3K5; the disease is diabetic cardiomyopathy.