Therefore, it is one of the markers most commonly used to assist in distinguishing thyroid lesions together to human bone marrow endothelial cell-1 (HBME-1) as a tumor marker of follicular origin and cytokeratin-19 (CK-19) with general intense and diffuse expression in papillary carcinoma and heterogeneous labeling in carcinoma and in follicular adenoma [12]. The gene discussed is KRT19; the disease is papillary carcinoma.