Among NHB males, the AD-GRS excluding APOE was associated with an OR of 3.60 (95% CI: 1.62, 8.00; P < 0.001) for dementia risk compared to an OR of 1.32 (95% CI: 0.66, 2.66; P = 0.436) among NHB females. Here, APOE is linked to dementia.