Moreover, COX-2 expression was observed in patients with Hashimoto's thyroiditis but not observed in normal thyroid tissue, multinodular goiter, or anaplastic carcinoma, suggesting that COX-2 expression in both of these thyroid pathologies may provide a basis for the relationship between carcinogenesis and autoimmunity [149]. The gene discussed is PTGS2; the disease is undifferentiated carcinoma.