In agreement with this notion, our lab has identified that COUP-TFII serves as one of the major angiogenic regulators within the tumor microenvironment to promote tumor angiogenesis in a spontaneous breast cancer model (MMTV-PyMT) and pancreatic cancer model (RIP1-Tag2)[6, 10, 18, 19]. The gene discussed is NR2F2; the disease is neoplasm.