Thus, these complicated hierarchies of signaling interactions are coordinated, and the orchestration among COUP-TFII, VEGF/VEGFR-2 signaling, and Notch signaling remains to be further elucidated, which might provide new insights for the underling mechanism of tumor angiogenesis and identify new targets for anti-angiogenic therapy. The gene discussed is NR2F2; the disease is neoplasm.