NR2F2 and neoplasm: Given the facts that there is limited success for anti-angiogenic therapy (Bevacizumab and Sunitinib) in patients and COUP-TFII potently targets multiple angiogenic and lymphangiogenic pathways within the tumor microenvironment, these studies prompted the rational basis that COUP-TFII might represent a potential therapeutic target and inhibition of COUP-TFII may offer an efficacious approach for anti-angiogenic intervention.