The frequency of COUP-TFII staining in the epithelium of metastatic ovarian cancers is significantly higher than the levels observed in the indolent ones, and tumors having higher COUP-TFII expression in the epithelium is associated with a trend toward greater likelihood of disease recurrence[30], supporting an oncogenic role of COUP-TFII in ovarian cancer at least in the epithelium compartment. This evidence concerns the gene NR2F2 and ovarian carcinoma.