SP1 and neoplasm: TA reduces cell survival, growth, and angiogenesis in tumor and cancer cells, including human xenograft tumor, human pancreatic cancer, human neuroblastoma, and mouse prostate cancer by regulating the activity of transcription factor Sp1; human head and neck cancer by regulating NADAG-1; human colorectal cancer via ESE-1/EGR-1; and human oral cancer by affecting the p38 mitogen-activated protein kinase signaling pathway [14, 19–23].