VEGFA and osteosarcoma: Interestingly, when grouped according to geographic settings of individual studies, the combined hazard ratio of Asian studies and non-Asian studies were 2.7 (95% CI: 1.35 - 3.39) and 1.51 (95% CI: 0.89-2.14), respectively, indicating that VEGF is an indicator of poor prognosis of osteosarcoma in Asian patients but not in non-Asian patients.