In this meta-analysis that included 1,497 cases and 3,213 controls, only variant rs4784227, located at 3′ of the TOX3 gene, a previously reported breast cancer risk locus at 16q12.1 (ref. 28), achieved genome-wide significance (P<5 × 10−8; T allele OR: 1.38 (95% CI: 1.24–1.54), P=3 × 10−9; P heterogeneity=0.24). The gene discussed is TOX3; the disease is breast carcinoma.