Consistent with this possibility, small molecule inhibition of GSK-3 was recently reported to deplete the population of prostate cancer stem/progenitor-like cells in PC3 and PC3M cells, as measured by the proportion of ALDHHIGH cells and reduced expression of stem/progenitor markers including NANOG and OCT4 [28]. The gene discussed is POU5F1; the disease is Familial prostate cancer.