EIF2S1 and cancer: The presence of cytoplasmic vacuoles is similar in appearance to the vacuoles observed in cancer cell lines treated with nelfinavir in vitro [14], and the red blood cell morphology is similar that observed in GADD34 knockout mice [25] that have increased levels of ER stress, because GADD34 dephosphorylates eif2alpha [26] and thereby reverses translation inhibition under stress conditions.