In addition, microglia in the spinal cords of late stage mSOD1G93A mice (130 days old) had enhanced phosphorylation of JAK2 compared with pre-onset stage mSOD1G93A mice (70 days old), providing a therapeutic rationale for JAK2 inhibition against ALS (Figure 1B, C). This evidence concerns the gene JAK2 and amyotrophic lateral sclerosis.