We next analyzed the prognostic implication of the HIF regulated genes involved in glutamate signaling in hepatocellular carcinoma (SLC1A1, SLC1A3, GRIA2, GRIA3 and FYN) using PROGgene [41] to analyze the GSE 10141 mRNA expression data set from 80 surgically resected hepatomas [42]. The gene discussed is FYN; the disease is hepatocellular carcinoma.