In a mouse model of pancreatic neuroendocrine tumor and in selected human cancers including breast cancer, increased interstitial fluid pressure was reported to stimulate increased expression of vesicular glutamate transporters, activation of NMDA-type glutamate receptors and downstream MEK-MAPK and CaM kinase signaling, leading to proliferation and invasion [60]. The gene discussed is MAP2K7; the disease is pancreatic neuroendocrine tumor.