AGTR1 and ischemia: Ischemia elevated brain water content of the lesioned hemispheres (right) of control ischemia rats to 83.3 ± 0.35%, while pre-ischemic blockade of AT1 receptors with candesartan (0.1 mg/kg) could significantly diminish BWC (mean ± SEM, 80.3 ± 0.28%, P<0.001, Fig. 3).